Taking this in combo with FEM for hormone support (not post partum or breastfeeding). I only take two on first ten days of my cycle when progesterone should be low, then increase by two every two days (as nearing last ten days of cycle when progesterone is high. I could feel my metabolism raise immediately; appetite increased, stopped being cold all the time. Bloating after meals went down significantly. Decreased heavy bleeding on period. Started with two a day and increased by 1 a day til I got to the full dose because it is very potent. Only thing is, after a few months of taking, effects have faded a little. Hard to find how placenta affects progesterone and estrogen, but I assumed because progesterone is high during pregnancy, the placenta would support progesterone production. After taking it, that appears to be true based on the improvement of my progesterone deficiency symptoms. I know from Dutch test I have estrogen dominance (like many people) and this did not increase those symptoms, which I wasn't sure about going into this.