I've had a lot of joint issues lately, including a badly injured knee. I thought this might be helpful. But within a few hours of my first dose I became uncomfortably lightheaded, and then developed nausea and intestinal distress. The better part of a day later, I still feel badly. If SAM-e agrees with you then this might be for you, but it isn't for me. The tablets are very large, so if swallowing is an issue these would be difficult to take. They don't have any significant odor. They shipped promptly. Nice that they are vegan.