It is too soon for me to give a proper appraisal of any positive or negative outcomes from trying this new supplement. However, since I have been given an opportunity to provide a review, I thought it might benefit others to remark on bottle size. I have noted a trend by some supplement vendors to spend more on upsized packaging than is warranted by their contents. The bottle for Autophagy Renew is a case in point. This is not a large bottle! Most consumers would give its size little thought. However, for the size and quantity of the capsules it contains (30 per bottle), it is extremely oversized. The bottle could easily have been reduced to half its size, even allowing space for readable labeling. How do I know? As an experiment, I opened five of the twelve bottles I purchased, and poured all of the capsules from those five bottles into a single bottle, with just enough space to permit one of the cotton balls inserted as filler in each bottle to fit snuggly at the top, At five to one, it is clear the bottles could have been significantly smaller. Why should this matter? In a word or two, resource conservation. Why expend unnecessary fossil fuels creating oversized plastic containers for products that will soon be consumed? Granted, some of those containers will be recycled, but others will end up in landfills, or worse still, in our oceans where sun and mechanical agitation will reduce them to micro-plastics negatively affecting the ecology of both marine and land biospheres, and the health of the earth's inhabitants, including humans. The extra carbon footprint required to create the larger bottles, as well as to recycle them, multiplied countless millions of times will only add to the burden of climate change and the many negative effects that is already producing on our planet. The value of a supplement, cost of production, marketing, transport, and storage may all be reasonable components of the price we pay to stay healthy, but oversized bottles should not!