I've been taking ThyroSoothe in place of Methimazole for Grave's Disease for over 3 months now. I started out taking the recommended dosage amount listed on the bottle, but unfortunately it wasn't enough to keep my antibodies in the proper range, so they started to go back up, which caused my hand tremors, "allergies", and other symptoms to start to come back . I then decided to double to dosage amount about 1 week ago and instantly started to notice a difference! My hand tremors are almost completely gone, my "allergies", and other symptoms have significantly subsided as well. I'll continue this dosage until my antibody numbers are steadily back in the proper range and then I'll reduce the dosage back down the the maintenance dose listed on the bottle.