I have been recovering from full-body concussions and significant brain injury. The inflammatory response to such injuries is through the roof sensitivities to various substances was part of the deal. Of the products I've tried for noise and inflammation (heat, pain) in the joints, this one very definitely made a noticeable difference within days - taking only two caps a day. I forgot to take them for a few days, and realized the irritations had returned, affecting my sleep again. Took some, and the symptoms were abated by nightfall. Now I'm aware of my system's demand, and am more regular about taking this. The spectrum and dosage of nutrients is key to its success. Sabinsa products are very well researched, and this particular Curcumin extract has shown amazing benefits for joints. Thank you for formulating this product!