Secure Denture Adhesive Cream provides up to 12 hours of strong hold and is the best I've found for keeping dentures in place. To use, start with clean dentures and apply a line of adhesive along the grooves. Place the denture in your mouth and press firmly for a few seconds, then repeat with the bottom denture. They'll feel secure right away and won't come out easily. At the end of the day, removal is easier thanks to the adhesive, but you'll still need to gently pull them down with your fingers or use dental floss to release them from your gums.