My wife is 75 years old. She, due to repeated kitchen work every day, have pain in most of the finger joints. She had operation and injections in the past. Our GP recommended her to take the ones, also bought from iherb, without MSM for years and she felt it helped. Most recently our GP suggested that the new ones with MSM would be better so I ordered 3 big bottles and let my wife tried. After may be a month or so, she told me that this ones with MSM is not as good as the old ones. I told my GP today and I prepare to order the old ones for her.