I take very very many Life Extension supplements, and have for decades. I'm very thankful for LE. However, when my Dr recommended calcium D-Glucarate, and I began taking it, I became seriously depressed and had horrific stress. It was scary, and it took weeks for me to realize it was this supplement causing it. After researching online, I found out many people had this reaction, and that it has to do with one's unique methylation. I don't yet understand the intricacies of it all, but I think folks should know this possibility exists for some folks. It was very frightening.