Good stuff. I'm glad I started taking Fisetin. This isn't medical advice - I'm merely relating what I do for myself. I take Fisetin at the same time as taking Nattokinase, and Serrapeptase. I take all three in the early evening on a full stomach. Well, I eat half my meal, then I take these three, then I finish my meal and have a big glass of mineral water. And then in the morning, on an empty stomach, I take Lumbrokinase. Don't take any of this stuff if you're on blood thinners, high blood pressure meds, OR ANY OTHER prescription meds unless you consult your own doctor. None of this is medical advice, so do your own research to figure our for yourself if you want to take this kind of stuff.